Drug Metabolism (ADME)

LAB Research Canada offers GLP-compliant preclinical studies designed to investigate the absorption, distribution, metabolism and excretion (ADME) to support drug discovery, safety evaluation and clinical development programs. 

Equipment

 Metabolism cages for all laboratory species
 CO² rodent cages (model Metabolica)
 Fully validated ß-counter (Model: Tri-Carb 2910^® TR)
 Sample Oxidizer (Model 307 Perkin Elmer)
 API5500 Q Trap for metabolite profiling/identification

Staff

 Senior scientists and managers with over 40 years of cumulative experience in contract ADME
 Supported by experienced dedicated ADME technicians
 ADME-experienced Study Directors

Services

 Mass Balance / excretion studies including CO²
 Isotopes used:   ¹⁴C /  ³H

Establishing mass balance and routes of excretion of an administered radioactive drug candidate is important to describe the distribution of the compound and possibly the interpretation of toxicology findings. Understanding the routes of excretion in animals will provide guidance in the evaluation of patients with compromised physiological functions (e.g. hepatic and renal impairment).

 Tissue Distribution studies (QTD)

Knowing the time course of a drug candidate's tissue distribution after administration may help in understanding the mechanism and course of action to help explain the observed toxicities.  The use of these studies provides an estimate of human exposure to radioactivity (dosimetry) in human radiolabeled mass balance/excretion studies.

QTD studies can be combined with mass balance studies, plasma/blood PK under a single protocol to save time and money.
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Species

 Rodents
 Dogs
 Primates
 Minipigs

Special Capabilities

 Mass Balance studies in minipgs
 Specialized techniques in PK/Mass balance sampling for non-rodents
 Fully validated instrumentation to comply with regulatory agencies

Support Services

 Bioanalytical Chemistry
 Pharmacokinetic analysis (WinNonLin)