GenETIC toxicOLOGY

LAB Research has over 20 years of experience and expertise and the facilities to perform all standard genotoxicity and mutagenicity tests.  LAB Research has experience in testing pharmaceuticals, biopharmaceuticals, chemicals, agrochemicals as well as test articles such as medical devices and mixtures. We can make the appropriate recommendations on how to proceed on a case-by-case basis and how to test even the most unusual products.

Our tests comply with the latest versions of the guidelines formulated by ICH and OECD and performed in accordance with the current OECD Good Laboratory Practice guidelines to ensure their acceptability world wide.

Study Types
Genotoxicity
 Bacterial reverse mutation test / Bacterial gene mutation test (the Ames test) – OECD 471
 Mammalian chromosome aberration test in-vitro / Mammalian cytogenic test
  (using human lymphocytes) – OECD 473
 Mammalian cell gene mutation test in-vitro (using mouse lymphoma L5178Y
  cells) – OECD 476
 Mammalian erythrocyte micronucleus test in-vivo – OECD 474

Cytotoxicity
The tests in-vitro that LAB Research offers are very varied, and many have been developed to solve particular problems. Examples of tests offered routinely include the following:

 Elution and/or Direct contact Cytoxicity test  (Medical Devices + other classes)
 Haemolysis and coagulation (testing of haemocompatibility of Medical Devices)

Support Services
 We offer screening versions of the genotoxicity tests, which are useful during the
  early development of new products.

Staff
 Our staff actively participates in the revision process of many national and international 
  guidelines to ensure that all tests comply fully with the latest requirements.
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