LAB Research Inc. offers the full range of immunology-based support services necessary for the development of biotechnology-derived therapeutics along with the experience and expertise necessary to conduct any required immunotoxicology studies.
In the new state of the art Montreal (Canada) facility, the immunology services group provides an industry-leading expertise in the conduct of GLP-compliant immunotoxicology evaluations. Our experts are abreast of the evolving regulatory requirements and are able to offer guidance in study and program design. Our facility in Denmark also offers a selection of these tests and services.
Whether developing a protein, nucleic acid or cell based therapeutic, our staff can provide full support from toxicology species justification, through assay development to final report submission.
Staff
PhD immunologists
Analysts with advanced degrees in immunology
Analysts in biological sciences
Veterinarian
Infrastructure
Modern laboratories
Dedicated, separate rooms for: Tissue culture Molecular biology General immuno-assays
Study Types Unintended immunosupression
Immunophenotyping for quantitation of lymphocyte lineages or biomarker expression
Immunohistochemical staining for cell lineage and apoptosis markers in fixed tissues
Cell mediated immunity (NK and CTL Cytotoxicity)
T-dependent antibody responses (KLH)
Host resistance models
Pseudoallergic reactions
Direct histamine release
Complement activation
Assessment of autoimmunity
Assays for anti-dsDNA and anti-nuclear antibodies
Markers of TH2 activation in rodents prone to develop autoimmune reactions
Screening for other autoantibody production in non-clinical toxicology studies
Adverse Immunostimulation
Our experts can advise on how to proceed in this rapidly evolving area of concern
Support Services
Immunogenicity analysis, including development of anti-drug antibody and neutralizing antibody assays.
Bioanalytical immunoassays for toxicokinetic and pharmacodynamic studies
Quantitative gene expression for biomarker analysis
Biodistribution and genomic integration analysis of nucleic acid therapeutics
Biodistribution and drug activity assays for enzyme products
Biodistribution of cell based therapeutics with PCR and immunohistochemistry
Tissue cross reactivity studies in support of monoclonal antibodies and other ligand binding therapeutics
Drug activity assays in support of tox species justification
Special Capabilities / Customized Assay Development
Flowcytometry techniques including 4-color analysis, intracellular antigen expression, and multiplexed analyte assays
Real time quantitative PCR for drug quantitation and gene expression analysis
Immunohistochemistry
Cell based assays with a wide variety of custom designs and endpoints
Preparation of isolated cells from tissues for; islet transplant models; analysis of tissue infiltrating lymphocytes; and drug biodistribution studies
Other custom biochemical and molecular biology services
Events
Tissue culture
