Immunology and Immunotoxicology Services

LAB Research Inc. offers the full range of immunology-based support services necessary for the development of biotechnology-derived therapeutics along with the experience and expertise necessary to conduct any required immunotoxicology studies.

In the new state of the art Montreal (Canada) facility, the immunology services group provides an industry-leading expertise in the conduct of GLP-compliant immunotoxicology evaluations. Our experts are abreast of the evolving regulatory requirements and are able to offer guidance in study and program design. Our facility in Denmark also offers a selection of these tests and services.

Whether developing a protein, nucleic acid or cell based therapeutic, our staff can provide full support from toxicology species justification, through assay development to final report submission.

Staff

• PhD immunologists
• Analysts with advanced degrees in immunology
• Analysts in biological sciences
• Veterinarian

Infrastructure

• Modern laboratories
• Dedicated, separate rooms for:
   Tissue culture
   Molecular biology
   General immuno-assays

Study Types
Unintended immunosupression

• Immunophenotyping for quantitation of lymphocyte lineages or biomarker expression
• Immunohistochemical staining for cell lineage and apoptosis markers in fixed tissues
• Cell mediated immunity (NK and CTL Cytotoxicity)
• T-dependent antibody responses (KLH) 
• Host resistance models 
  
  Pseudoallergic reactions
• Direct histamine release
• Complement activation
  
  Assessment of autoimmunity
• Assays for anti-dsDNA and anti-nuclear antibodies
• Markers of TH2 activation in rodents prone to develop autoimmune reactions
• Screening for other autoantibody production in non-clinical toxicology studies
  
  Adverse Immunostimulation
• Our experts can advise on how to proceed in this rapidly evolving area of concern

Support Services

• Immunogenicity analysis, including development of anti-drug antibody and neutralizing antibody assays. 
• Bioanalytical immunoassays for toxicokinetic and pharmacodynamic studies 
• Quantitative gene expression for biomarker analysis 
• Biodistribution and genomic integration analysis of nucleic acid therapeutics
• Biodistribution and drug activity assays for enzyme products
• Biodistribution of cell based therapeutics with PCR and immunohistochemistry
• Tissue cross reactivity studies in support of monoclonal antibodies and other ligand binding therapeutics 
• Drug activity assays in support of tox species justification

Special Capabilities / Customized Assay Development

• Flowcytometry techniques including 4-color analysis, intracellular antigen expression, and multiplexed analyte assays
• Real time quantitative PCR for drug quantitation and gene expression analysis
• Immunohistochemistry
• Cell based assays with a wide variety of custom designs and endpoints
• Preparation of isolated cells from tissues for; islet transplant models; analysis of tissue infiltrating lymphocytes; and drug biodistribution studies 
• Other custom biochemical and molecular biology services

Species: Rodent and Non-Rodent