Inhalation Toxicology

As part of our recent facility expansion, LAB Research Canada opened a state of the art rodent, dog and primate inhalation facility to offer acute through chronic inhalation toxicity studies of large and small molecule pharmaceutical products. 

Facilities

 Total of 12 (7 rodent and 5 non-rodent) dedicated inhalation suites
 4 suites to be equipped and operational in 2009
 8 additional suites to be phased in commencing in 2009
 5 to 6 containment cabinets per rodent suite to prevent cross contamination
 Separate control article exposure rooms for large animal suites to prevent cross-contamination
 Redundant systems (back-up pumps and ventilation, UPS/back-up generators)

Equipment

 Nose-only stainless-steel exposure chambers for rodents (flow-through and flow-past)
 Modular chamber capacity (up to 80+ rodents per chamber)
 Dog or primate exposure (mask) capacity for up to 8 large animals/stainless-steel chamber concurrently
 Computer-monitored and controlled exposure systems in each suite
 Atmosphere generation: dust feeds, nebulizer, MDI, other
 Particle size analyzers 

Staff
 2 inhalation toxicologists with cumulative 30+ years in inhalation toxicology
 7 inhalation technologists with cumulative 30+ years experience in inhalation delivery
 Supported by a toxicology staff of well over 100 technicians 

Study Types

 Single dose
 Sub-chronic
 Chronic
 Safety pharmacology

Species

 Rat
 Dog
 Primate

Additional Services

 Analytical chemistry support
 LC-MSMS
 HPLC
 Toxicokinetics (sampling and non-compartmental analysis)
 Clinical pathology
 Immunology
 Pathology