Pharmacokinetic / Toxicokinetic Studies at LAB Research Inc.

LAB Research three main facilities, located in Montreal, CANADA, Copenhagen, DENMARK and Veszprem, HUNGARY, offer close to 300,000 sq.ft. of vivarium and supporting laboratories for the conduct of GLP-compliant pharmacokinetic and toxicokinetic studies on pharmaceuticals and biotechnology-derived products.  Studies are conducted in all rodent and non-rodent species, including primates and mini-pigs and are supported by LAB Research’s bioanalytical and immunology services which provide LC-MS-MS, HPLC and immuno-assay (e.g. ELISA) analyses in biological matrices. 

Non-compartmental modelling is conducted, with full or sparse-sampling designs, using fully GLP-validated WinNonLin software.  In addition to routine blood collections (e.g. sublingual or tail vein in rats), our technologists use a specialized jugular sampling technique, to collect serial blood samples from individual rats without the need for anesthesia or cannulation

Staff

• Pharmacokineticist
• Immunologists
• Analytical and Bioanalytical Chemists
• Animal health technologists
• Toxicologists

Study Durations

• Single dose
• Repeated dose

Species
• Rodents
• Dogs
• Primates
• Rabbits
• Mini  and micro-pigs

Routes of Administration • Oral (gavage, capsule, pills) • Intravenous • Intravenous infusion • Subcutaneous • Dermal • Inhalation • Intradermal • Intramuscular • Intraperitoneal

• Intranasal • Intravaginal/intraurethral • Intra-rectal • Intra-vesicular • Intra-vitreal • Ocular • Endoscope-assisted administration (e.g. direct to duodenum)

Special Capabilities

• Permanent dog & primate PK colonies
• Radio-labelled studies

Support Services

• Analytical & Bioanalytical Chemistry
• Pharmacokinetic modelling (WinNonLin)
• Immunology